The discovery of a new mechanism that regulates brown adipose tissue, published in ‘Cell’

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Last edited Thu May 24, 2012, 03:49 AM - Edit history (1)

http://atomiumculture.eu/content/discovery-new-mechanism-regulates-brown-adipose-tissue-published-‘cell’


Bone morphogenetic protein 8B (BMP8B) plays a key role in regulating thermogenesis in brown adipose tissue, according to the findings of a research work published in Cell, the journal with the most impact on the field of biomedicine and molecular biology. The research group of Molecular Biology and Gene Regulation of the Adipose Tissue and its Diseases, led by Francesc Villarroya, professor at the Department of Biochemistry and Molecular Biology and director of the Institute of Biomedicine of the UB (IBUB), affiliated centre to the campus of international excellence Barcelona Knowledge Campus (BKC) has taken part in the research.

The new research work, which presents a new mechanism to regulate brown adipose tissue, is also signed by experts from the Research Group of de NeurObesity (University of Santiago de Compostela), led by lecturer Miguel López, in collaboration with research teams from research centres in Iowa (United States), Stockholm (Sweden) and Cambridge (United Kingdom).

Brown adipose tissue: the mechanism for thermogenesis
One of the basic causes related to the epidemic of obesity is the malfunctioning of the brown adipose tissue. Unlike white adipose tissue, which is the most common type of fat, brown adipose tissue does not store up lipids. Instead, it oxidizes them in order to obtain energy which is released as heat. This phenomenon is known as thermogenesis.

Hence, brown adipose tissue helps to “burn more calories” and to produce body heat from fat. For this reason, this special type of fat has attracted the attention of the research group as a potential therapeutic target to treat obesity. However, molecular mechanisms that regulate its functioning are not well known and further research is still needed.

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1. Page not found, but here's the article link

http://www.cell.com/abstract/S0092-8674%2812%2900507-7

SUMMARY
Thermogenesis in brown adipose tissue (BAT) is
fundamental to energy balance and is also relevant
for humans. Bone morphogenetic proteins (BMPs)
regulate adipogenesis, and, here, we describe a
role for BMP8B in the direct regulation of thermogen-
esis. BMP8B is induced by nutritional and thermo-
genic factors in mature BAT, increasing the response
to noradrenaline through enhanced p38MAPK/CREB
signaling and increased lipase activity. Bmp8bÀ/À
mice exhibit impaired thermogenesis and reduced
metabolic rate, causing weight gain despite hypo-
phagia. BMP8B is also expressed in the hypothal-
amus, and Bmp8bÀ/À mice display altered neuropep-
tide levels and reduced phosphorylation of
AMP-activated protein kinase (AMPK), indicating
an anorexigenic state. Central BMP8B treatment
increased sympathetic activation of BAT, dependent
on the status of AMPK in key hypothalamic nuclei.
Our results indicate that BMP8B is a thermogenic
protein that regulates energy balance in partnership
with hypothalamic AMPK. BMP8B may offer a
mechanism to specifically increase energy dissipa-
tion by BAT.

[postulater]

2. Thanks, good info!