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We tend to think of our bodies changing only slowly once we reach adulthood. So I was fascinated to discover that, in fact, we're changing all the time and constantly rebuilding ourselves. Talk about our skin.
Iris: Most people don't even think of the skin as an organ. In fact, it's our largest one.
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The cells there are replaced roughly every month or two. That means we lose approximately 30,000 cells every minute throughout our lives, and our entire external surface layer is replaced about once a year.
Very little of our physical bodies lasts for more than a few years. Of course, that's at odds with how we perceive ourselves when we look into the mirror. But we're not fixed at all. We're more like a pattern or a process. And it was the transience of the body and the flow of energy and matter needed to counter that impermanence that led us to explore our interconnectedness with the universe.
You have a fascinating discussion about age. Describe how different parts of the human body age at different speeds.
Iris: Every tissue recreates itself, but they all do it at a different rate. We know through carbon dating that cells in the adult human body have an average age of seven to ten years. That's far less than the age of the average human, but there are remarkable differences in these ages. Some cells literally exist for a few days. Those are the ones that touch the surface. The skin is a great example, but also the surfaces of our lungs and the digestive tract. The muscle cells of the heart, an organ we consider to be very permanent, typically continue to function for more than a decade. But if you look at a person who's 50, about half of their heart cells will have been replaced.
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How has writing this book changed your view of life—and your view of each other?
Karel: There are two things that struck me, one that I had no idea about. The first is what Iris described earlier—the impermanence of our bodies. As a physicist, I thought the body was built early on, that it would grow and be stable. Iris showed me, over a long series of dinner discussions, that that's not the way it works. Cells die and rebuild all the time. We're literally not what were a few years ago, and not just because of the way we think. Everything around us does this. Nature is not outside us. We are nature.
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I was surprised that an astrophysicist wouldn't be aware of this, but thinking back, I remember when I first really understood this, it was during a conversation with some friends way back in college about Eastern religions, where impermanence is a key concept. So if someone didn't have those conversations, their understanding of science would be hindered.
Not only are cells constantly replaced, but the components of cells are constantly being replaced. The "skin" of a cell, it's surface membrane, is constantly being regenerated, including the receptors, which sprout from the nucleus and grow out to the surface like lily pads in a pond.
And even the atoms within cells are constantly being replaced, including the calcium atoms in bones, the most solid parts of our bodies:
http://en.wikipedia.org/wiki/Calcium_metabolism
Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Calcium release from bone is regulated by parathyroid hormone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin.
Low calcium intake may also be a risk factor in the development of osteoporosis. In one meta-analysis, the authors found that fifty out of the fifty-two studies that they reviewed showed that calcium intake promoted better bone balance.[6] With a better bone balance, the risk of osteoporosis is lowered.
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