The geographic origin of AIDS is now known

[KamaAina]

http://medicalxpress.com/news/2014-11-geographic-aids.html

A study published in Science magazine reveals for the first time where, when and how the world's AIDS pandemic originated. Thanks to a statistical analysis of all the genetic data available on the human immunodeficiency virus (HIV), an international research team has just confirmed that the scourge broke out in 1920 in Kinshasa, the capital of what is now the Democratic Republic of the Congo. By comparing this result with historical data, researchers explain how, from a single contamination by a chimpanzee, HIV spread to humans....

To determine where and when the epidemic originated, researchers compared the genetic diversity of the viruses collected in the countries of the Congo Basin, considered potential birthplaces. The result: the origin of the scourge was Kinshasa, the capital of what is now the Democratic Republic of the Congo, and dates back to 1920.

Once the geographic origin of HIV was determined, scientists were able to link their genetic data on the virus' evolution with historical data, to determine the circumstances that enabled its outbreak in Kinshasa and its spread among human populations. Belgian colonial archives on the former Zaire reveal that at the beginning of the century a great deal of trade took place by river (ivory, rubber, etc.) between South-East Cameroon and Kinshasa. This could explain why the human epidemic broke out in the Congolese capital and not in Cameroon where the chimpanzees that contaminated humans are found.

Then between 1920 and 1950, urbanisation and the development of transport, particularly railways, made Kinshasa one of the most connected cities in Central Africa. At the end of the 1940s, over a million people passed through the city each year to reach the north or south of the country or travel to neighbouring countries. This unusual cocktail of factors, combined with the virus' genetic adaptability, led to its very rapid spread throughout the country (large like West Europe) as well as secondary outbreaks as far as South and East Africa. Later, after the 1960s, other social changes, such as the rise in prostitution and the use of non-sterile needles in public health initiatives, undoubtedly contributed to transforming small outbreaks of infection into a real pandemic.

[TexasProgresive]

1. K&R

[Spider Jerusalem]

2. I thought this was already known

Jacques Pépin's "The Origins of AIDS", published in 2011, pinpoints Kinshasa (formerly Leopoldville) and Brazzaville as the epicentre of the epidemic strain of HIV, circa 1920 or so. http://www.nytimes.com/2011/10/18/health/18aids.html?pagewanted=all&_r=0

I'd recommend it as a good and accessible overview of the best evidence on how and why HIV became an epidemic.

[area51]

4. I thought this sounded familiar. n/t

[niyad]

3. k and r and thank you.