Moderna...says its coronavirus vaccine trial produced 'robust' immune response

[Nevilledog]

Moderna shares jump as much as 16% after company says its coronavirus vaccine trial produced ‘robust’ immune response


https://www.cnbc.com/2020/07/14/moderna-says-its-coronavirus-vaccine-trial-produced-robust-immune-response-in-all-patients.html


Moderna’s shares soared after the company said its potential vaccine to prevent Covid-19 produced a “robust” immune response in all 45 patients in its early stage human trial, according to newly released data published Tuesday evening in the peer-reviewed New England Journal of Medicine.

Moderna’s stock rose more than 16% in after-hours trading on the news.

All 45 patients produced neutralizing antibodies, which scientists believe is important for building immunity and provided more promising data that the vaccine may give some protection against the coronavirus. In the trial, each participant received a 25, 100 or 250 microgram dose, with 15 people in each dose group. Participants received two doses of the potential vaccine.

After two vaccinations, the vaccine elicited a “robust” immune response in all participants in all dose cohorts, Moderna said. The company said the levels of neutralizing antibodies in patients in the high dose group were fourfold higher than in recovered Covid-19 patients.

“These Phase 1 data demonstrate that vaccination with mRNA-1273 elicits a robust immune response across all dose levels and clearly support the choice of 100 µg in a prime and boost regimen as the optimal dose for the Phase 3 study,” Moderna’s chief medical officer, Tal Zaks, said in a statement. “We look forward to beginning our Phase 3 study of mRNA-1273 this month to demonstrate our vaccine’s ability to significantly reduce the risk of COVID-19 disease.”

*snip*

[RT Atlanta]

1. politics aside

whatever is going to be promising, clinically tested, with verifiable results, I am all for it.

here's to hoping some of these trials advance to something meaningful that will save lives.

[SoonerPride]

2. Encouraging news. I hope those antibodies last

My fear is that they fade after 8 weeks or so.

[triron]

4. It's T cells that last. I think.

[LonePirate]

3. This is good news. The question now is how long the immune response lasts.

Does the response last for a few weeks? A few months? A year? Longer? Basically, will the vaccine be something most people take once, like the MMR shot? Or will we need to receive yearly (or bi-yearly) vaccinations?

[Thekaspervote]

5. It my understanding that he mRNA vaccines work to give longer lived immunity

The m standing for memory, i.e. the virus is recognized longer as an invader and an attack is launched to stop it

[PSPS]

6. When a story begins "Moderna's shares soared after the company said...," I think pump & dump

[Nevilledog]

7. Tried to get that in the title but too long. That's why I put full title in post.

It always feels skeevy talking about stock prices for developing a vaccine for a pandemic.

[Initech]

8. This is definitely good news.

Now we need to see how long the immune response lasts before we can pop the champagne.