General Discussion
Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsAbout Covid-19----some facts:
***It not only is not "just another type of flu", it is not even related. Caused by a totally different critter. It IS related to SARS and MERS.
***It is somewhere between 20 and 35 times more likely to be fatal than is the flu.
***Doctors in China who have performed autopsies on people for whom Covid-19 proved fatal say that it resembles a combination of SARS and AIDS.
***Donald Trump is only concerned about its negative impact on the stock markets; he cares not one whit about dying Americans. (OK, that was an opinion, not a fact, but---does anyone disagree?)
unblock
(52,253 posts)does it compromise the immune system somehow?
Zoonart
(11,869 posts)those recovered.
Ms. Toad
(34,075 posts)for about a week now. The autopsy results are new.
https://www.globaltimes.cn/content/1181121.shtml
This finding suggests that 2019-nCoV [the new coronavirus] may be significantly different from the Sars coronavirus in the infection pathway, the scientists said in a paper published this month on Chinaxiv.org, a platform used by the Chinese Academy of Sciences to release scientific research papers before they have been peer-reviewed.
https://www.scmp.com/news/china/society/article/3052495/coronavirus-far-more-likely-sars-bond-human-cells-scientists-say
BUT - note that the second (earlier) paper was published by an entity that publishes before peer review.
moriah
(8,311 posts).... just because it may use furin convertase to "cut" itself at one point in its reproductive cycle.
Proteolytic cleavage of the S glycoprotein can determine whether the virus can cross species, e.g. from bats to humans. For example, the S glycoprotein from a MERS-like CoV from Ugandan bats can bind to human cells but cannot mediate virus entry. However, if the protease trypsin is included during infection, the S glycoprotein is cleaved and virus entry takes place. This observation demonstrates that cleavage of the S glycoprotein is a barrier to zoonotic coronavirus transmission.
Examination of the protein sequence of the S glycoprotein of SARS-CoV-2 reveals the presence of a furin cleavage sequence (PRRARS|V). The CoV with the highest nucleotide sequence homology, isolated from a bat in Yunnan in 2013 (RaTG-13), does not have the furin cleavage sequence. Because furin proteases are abundant in the respiratory tract, it is possible that SARS-CoV-2 S glycoprotein is cleaved upon exit from epithelial cells and consequently can efficiently infect other cells. In contrast, the highly related bat CoV RaTG-13 does not have the furin cleavage site.
Whether or not the furin cleavage site within the S glycoprotein of SARS-CoV-2 is actually cleaved remains to be determined. Meanwhile, it is possible that the insertion of a furin cleavage site allowed a bat CoV to gain the ability to infect humans. The furin cleavage site might have been acquired by recombination with another virus possessing that site. This event could have happened thousands of years ago, or weeks ago. Upon introduction into a human likely in an outdoor meat market the virus began its epidemic spread.
Furins are also known to control infection by avian influenza A viruses, in which cleavage of the HA glycoprotein is needed for entry into the cell. Low-pathogenic avian influenza viruses contain a single basic amino acid at the cleavage site in the HA protein which is cleaved by proteases that are restricted to the respiratory tract. Insertion of a furin cleavage site in the HA of highly pathogenic avian H5N1 influenza viruses leads to replication in multiple tissues and higher pathogenicity, due to the distribution of furins in multiple tissues.
Went over five paragraphs, but he explains it better than this other journal article, which also explains quite a bit with far more detailed graphics and charts.
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Essentially a ton of viruses can evolve to use furin, an enzyme very common in our lungs, to help in its reproductive capacities. All colds and flus weaken a person's "immune system" (as in, ability to fight off a secondary infection, which I'm sure was happening in China as well as viral pneumonia). This one, especially if it is replicating easily in the lower lungs thanks to the abundance of furin convertase there, will be a nasty one.
But people jump on words "like HIV and Ebola", and we have Alex Hoax already saying that this was bioengineered because of this research about the virus potentially cleaving itself with furin.
The virus's mutated sequence has as much similarity to Yellow Fever and RSV as it does to "HIV and Ebola". And clearly since this virus is sparing children where RSV almost exclusively causes issues in young infants, and isn't causing jaundice, the comparisons are not quite valid except that furin is a convertase enzyme that if a previously zoonotic virus "learns" to use, it can cause increased ability to replicate in human cells where furin is abundant.
Thank you.
I wish I had more than a cursory understanding of what you've posted here.
Control-Z
(15,682 posts)Thanks!
Atticus
(15,124 posts)Regarding the higher rate of fatalities, this was simply the range from the 2% death rate stated by the Trump team and the now widely quoted "over 3.4%" by the experts at the WHO.
So far, I have not re-located where I read or heard about the autopsies. Will post it if/when found.
Control-Z
(15,682 posts)MelissaB
(16,420 posts)Frustratedlady
(16,254 posts)and keep Trump from making any official comments about the virus, testing, the treatment plans and absolutely no comments about the survival rate. It may be customary to reserve comment that would upset the POTUS, but this is an unusual situation and someone needs to take control of this idiot in the oval.
By attempts to put people at ease, he is scaring the hell out of many. Same with Pence. Let the experts conduct any press releases or public comments.
Same with the stock market.
If Trump was really concerned, he would also cancel all his rallies. They are just ego expanders and we sure don't need that.
obamanut2012
(26,080 posts)Good lord, stop spreading so much misinformation.
MelissaB
(16,420 posts)Chinese doctors say autopsies of coronavirus victims suggest the deadly illness is like a combination of SARS and AIDS that can cause irreversible lung damage even if the patient recovers.
The grim finding was reported on by Communist Party mouthpiece the Global Times on Friday, after a paper by Wuhan doctors published in the Journal of Forensic Medicine earlier in the week went viral on Chinese social media.
The influence of COVID-19 on the human body is like a combination of SARS and AIDS as it damages both the lungs and immune systems, Peng Zhiyong, director of the intensive care unit of the Zhongnan Hospital of Wuhan University in Wuhan, told the Global Times.
Dr Peng was commenting on the paper by Liu Liang, a forensic specialist from the Tongji Medical College at Huazhong University of Science and Technology, whose team had conducted nine autopsies of coronavirus patients as of February 24.
The autopsy results Liu shared inspired me a lot. Based on the results, I think the most important thing now is to take measures at an early stage of the disease to protect patients lungs from irreversible fibrosis, Dr Peng told the outlet.
More: https://www.news.com.au/lifestyle/health/health-problems/chinese-doctors-say-coronavirus-like-a-combination-of-sars-and-aids-can-cause-irreversible-lung-damage/news-story/f58f19c5eeae99b845c54e2d2b9305ca
Atticus
(15,124 posts)MelissaB
(16,420 posts)Atticus
(15,124 posts)doctor who is an ABC contributor. What is your source for the "proven false" ?
cwydro
(51,308 posts)Thanks.