In August 1996, a patient in Kansas developed an Enterobacter cloacae bloodstream infection (BSI) shortly after receiving Albuminar, a brand of human albumin. Albuminar contamination
was suspected.
...
During the epidemic period, 451 patients at VCSF received either Centeon or Alpha Therapeutic (Albutein, Los Angeles, CA) albumin. A total of 691 vials of Centeon Albuminar, lot P61205, were used during this period. The number of patients who received Albuminar from this lot is uncertain, since other lots of Albuminar were also used during the epidemic period and lot numbers were not consistently recorded in the patient medical records or pharmacy records.
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Albumin constitutes >60% of blood plasma proteins <1>. Human albumin, a licensed biological product, may be purified from the plasma of human donors by cold ethanol fractionation. Albumin has frequently been used as a resuscitation fluid for shock, as a nutritional intervention for protein malnutrition, and as a treatment for hepatic cirrhosis with ascites or nephrotic syndrome with edema. However, the appropriate clinical indications for the use of albumin have been debated since the product was developed in the 1940s <2>, and a recent review suggests that administration of albumin to critically ill patients may increase mortality <3>. It is more expensive than other products used for the same indications, such as nonprotein colloid (e.g., hetastarch and dextran) and crystalloid (e.g., lactated Ringer’s and saline) solutions.
1. Guyton AC. Textbook of medical physiology. 7th ed. Philadelphia:WBSaunders,
1986:208.
University of Chicago Press - Infections Traced to Contaminated Human AlbuminHow the contaimination could occur? Something like this perhaps?
Factor 8: The Arkansas Prison Blood Scandal is a feature length documentary by Arkansas filmmaker and investigative journalist Kelly Duda. Through interviews and presentation of documents and footage, Duda alleges that for more than two decades, the Arkansas prison system profited from selling blood plasma from inmates infected with viral hepatitis and AIDS. The documentary contends that thousands of victims who received transfusions of a blood product derived from these plasma products, "Factor 8", died as a result.
Factor 8 uses in-depth interviews and key documents as well as never-before-seen footage, to allege wrongdoing at the Arkansas state government under Governor Bill Clinton's leadership, and at the United States federal level.
Through in-depth interviews with a number of players, including victims in Canada who contracted the diseases, US state prison officials, former employees, high-ranking Arkansas politicians and inmate donors, Factor 8 examines a prison blood-harvesting scheme run by prisoners to earn them an income; the blood was then sold by blood companies for millions of dollars. The harvested plasma was then shipped around the world, where it has been reported to have infected thousands of haemophilia patients. Haemophilia is a genetic condition which prevents clotting.
In the United States, lawyers have won settlements for 8,000 US haemophilia sufferers after they were given infected blood
. In 2002 the UK Government promised an inquiry if it was proven infected blood came from a US prison, although to date no inquiry has taken place. The UK Public Health Minister, Caroline Flint, has said: "We are aware that during the 1970s and 80s blood products were sourced from US prisoners" and the UK Haemophilia Society has called for a Public Inquiry. The UK Government maintains that the Government of the day had acted in good faith and without the blood products many patients would have died. In a letter to Lord Jenkin of Roding the Chief Executive of the National Health Service (NHS) informed Lord Jenkin that most files on contaminated NHS blood products which infected people with HIV and hepatitis C had unfortunately been destroyed "in error". Fortunately, copies that were taken by legal entities in the UK at the time of previous litigation may mean the documentation can be retrieved and consequently assessed
Factor 8: The Arkansas Prison Blood Scandal