(More at the link. Basic conclusion: insufficient data available to judge the safety of PAVA use)
PAVA has the following chemical structure:
Use of PAVA as incapacitant spray
3. The spray used by Sussex Police consists of a 0.3% solution of PAVA in 50% aqueous ethanol. It is dispensed from hand held canisters (containing nitrogen as propellant) as a coarse liquid stream; the spray pattern is stated to be directional and precise. The canisters contain 50 ml of solution. The instructions are to aim directly at the subject's face, especially the eyes, using a half second burst (still air) or one second burst (moving air), repeating if necessary. The maximum effective range is 8-15 feet and the instructions are not to use at a distance of under 3 feet because of the risk of pressure injury to the eye. The effectiveness of the spray depends on eye contact with small amounts reaching the eyes producing the desired effect. In some cases officers will miss and use more than one burst.
4. Studies on the particle size of the spray indicate that the bulk of the droplets are over 100 mm but a small proportion (1-2%) is in the range 2-10 mm, and there may be traces below 2 mm. Thus it is unlikely that large amounts of PAVA will reach the respiratory system, although the possibility of some reaching the lungs cannot be excluded. It is not possible to estimate the respirable dose.
Toxicity of PAVA
Absorption, Metabolism, Elimination and Excretion
5. Only limited data are available to assess oral absorption of PAVA; the compound shows higher acute toxicity by the parenteral rather than by the oral route suggesting relatively poor oral absorption. More extensive data are available regarding skin absorption, particularly from ointments designed for topical medical use. PAVA has been shown to be well absorbed through the rabbit skin (50-70% in 14 hours) when applied in such ointments (hydrophilic, oil-water emulsions) under an occlusive dressing.(1) More limited skin absorption (12% over 72 hours) was reported in the rat using an aqueous vehicle (phosphate buffered saline) and a non-occlusive dressing.(2) The only data available on skin absorption from aqueous ethanol are from in-vitro studies using rat skin when the rate of absorption from 50% aqueous ethanol was shown to be considerably faster than that when phosphate buffered saline was used as vehicle.(2) It should therefore be assumed that there will be some absorption of PAVA following skin or eye contact with the spray.
6. Once absorbed PAVA is distributed throughout the body, extensively metabolised and rapidly excreted (most within 24 hours). The main route of metabolism is hydrolytic cleavage of the amide bond which occurs in liver and other tissue including the skin.(2) There is some evidence for aliphatic hydroxylation, as also occurs with capsaicin.(3)
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more:
http://www.advisorybodies.doh.gov.uk/cotnonfood/pava.htm