Potential prevention of beta amyloid by Sylmarin (Milk Thistle)

[HysteryDiagnosis]

http://www.ncbi.nlm.nih.gov/pubmed/21071836


Biosci Biotechnol Biochem. 2010 Nov 23;74(11):2299-306. Epub 2010 Nov 7.
Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.

Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.

Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Abstract

Alzheimer's disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.

PMID: 21071836 Free Article

[WhiteTara]

1. nice to see this other great benefit

from milk thistle.

[HysteryDiagnosis]

2. They grow like weeds round here.... well, they are a weed I'm pretty sure. n/t

[WhiteTara]

3. weed or herb...it's all in the garden placement. n/t

[HysteryDiagnosis]

4. In case you didn't see this:

http://www.democraticunderground.com/discuss/duboard.php?az=show_mesg&forum=222&topic_id=98699&mesg_id=98700

[WhiteTara]

5. this makes me know that next summer

I'll wild harvest my own and make teas from the fresh herbals. I'm sure that would be a very potent cleanser. Meanwhile, little white caps will do. (I wonder why there's white powder in the caps when the seeds are black.)

[emilyg]

6. I take Milk Thistle every

day for my gallbladder. Good news.