http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2006-07-14T000518Z_01_PAR400274_RTRUKOC_0_US-ULTRASOUND-GOOD-DRUGS-BAD-KNEE-INJURY.xml&archived=False Treatment with low-intensity pulsed ultrasound can hasten the healing of torn ligaments in the knee, while the use of NSAID drugs, such as Celebrex (celecoxib) and Motrin (ibuprofen), has the opposite effect, findings from an animal study suggest.
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Dr. Stuart J. Warden, from Indiana University in Indianapolis, and colleagues assessed healing in 60 adult rats with experimentally induced injuries to ligaments in both knees. The animals were treated with Celebrex in a carrier solution or with the carrier alone. In each animal, one knee was treated with active ultrasound, while the other received ultrasound without the equipment actually being on.
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Active ultrasound "accelerated ligament healing," Warden told Reuters Health, while "celecoxib did the opposite. Knees treated with these modalities reached the same level of healing, it just took longer when celecoxib was given."
When both Celebrex and active ultrasound were given, the effects canceled each other out. The end result was that these knees healed about as fast as those exposed to inactive ultrasound and vehicle solution.
As to how NSAIDs impair ligament healing, Warden said that it is thought to relate to a reduction in the formation of collagen, the protein responsible for the strength of ligaments.