Polycystic Ovarian Syndrome vs Lipoic Acid

[HysteryDiagnosis]

Geez, they don't understand how this can be. How gosh.


J Diabetes Sci Technol. 2010 Mar 1;4(2):359-64.
Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.
Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID.

Department of Medicine, University of California, San Francisco, Diabetes Center, San Francisco, California 94143 , USA. [e-mail]
Abstract

BACKGROUND: The purpose of this study was to determine whether a preparation of controlled-release alpha lipoic acid (CRLA) influences features of the polycystic ovary syndrome (PCOS).

METHODS: We administered CRLA 600 mg twice daily for 16 weeks to six lean, nondiabetic patients with PCOS. Insulin sensitivity was measured by the euglycemic, hyperinsulinemic clamp. Plasma lipids were measured by vertical ultracentrifugation. Oxidative stress markers were measured in serum. RESULTS: At the end of 16 weeks of CRLA treatment, there was a 13.5% improvement in insulin sensitivity as determined by the euglycemic, hyperinsulinemic clamp (p < .03). There was also a lowering of triglyceride levels (p < .04) and a shift in the distribution of low-density lipoprotein (LDL) particles toward the larger, more buoyant LDL subclass fraction.

Two of the subjects who were not on oral contraception had an increased number of menstrual cycles. Controlled-release alpha lipoic acid treatment, however, was neither associated with an increase in plasma antioxidant capacity nor with a reduction in plasma lipid oxidation products.

CONCLUSIONS: These data suggest that the CRLA has positive effects on the PCOS phenotype. The effects of CRLA, however, may have been exerted through a mechanism not involving changes in oxidative stress. (c) 2010 Diabetes Technology Society.

PMID: 20307398 PMCID: PMC2864173

[HysteryDiagnosis]

1. Clinical Trials with Lipoic Acid in the works or completed

Rank Status Study
1 Completed Effects of Quinapril 40 mg With Alpha Lipoic Acid or Placebo on Diabetes and Hypertension
Conditions: Diabetes; Hypertension
Interventions: Drug: Quinapril (Accupril) plus Alpha Lipoic Acid; Drug: accupril, placebo; Drug: accupril, alpha lipoic acid
2 Not yet recruiting The Effects of Lipoic Acid on Glycaemic Control in Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
Intervention: Drug: Lipoic acid
3 Recruiting Alpha-Lipoic Acid in Preventing Hearing Loss in Cancer Patients Undergoing Treatment With Cisplatin
Conditions: Ototoxicity; Unspecified Adult Solid Tumor
Interventions: Drug: alpha-lipoic acid; Behavioral: Audiology; Biological: laboratory biomarker analysis
4 Recruiting Lipoic Acid and Prevention of Heart Disease
Condition: Atherosclerosis
Interventions: Dietary Supplement: R-alpha lipoic acid; Dietary Supplement: Placebo
5 Completed
Has Results Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease
Conditions: Alzheimer's Disease; Oxidative Stress; Dementia; Hyperlipidemia; Inflammation
Interventions: Dietary Supplement: Fish Oil; Dietary Supplement: Fish Oil and Lipoic acid; Other: Placebo
6 Not yet recruiting Lipoic Acid and Omega-3 Fatty Acids for Alzheimer's Disease
Condition: Alzheimer's Disease
Intervention: Dietary Supplement: lipoic acid and fish oil concentrate
7 Not yet recruiting Defining the Anti-inflammatory Role of Lipoic Acid in Multiple Sclerosis
Condition: Multiple Sclerosis
Intervention: Dietary Supplement: Lipoic Acid
8 Not yet recruiting The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion
Conditions: Type 2 Diabetes; Prediabetes
Intervention: Drug: alpha lipoic acid
9 Not yet recruiting The Role of R-Alpha Lipoic Acid in the Treatment of Atherosclerotic Vascular Disease
Condition: Atherosclerosis
Intervention: Dietary Supplement: R-alpha lipoic acid
10 Active, not recruiting A Study of the Pharmacokinetics and Immunologic Effects of Lipoic Acid in Multiple Sclerosis
Condition: Multiple Sclerosis
Interventions: Drug: oral lipoic acid (LA); Drug: lipoic acid (LA) with fish oil and LA without fish oil; Drug: R lipoic acid
11 Recruiting Lipoic Acid to Treat Chronic Inflammatory Demyelinating Polyneuropathy
Conditions: CIDP; Chronic Inflammatory Demyelinating Polyneuropathy
Intervention: Drug: lipoic acid
12 Recruiting Effects of Lipoic Acid and Eicosapentaenoic Acid (EPA) in Human Obesity
Conditions: Obesity; Body Fat; Insulin Resistance
Intervention: Dietary Supplement: Double blind dietary intervention with EPA and lipoic acid
13 Completed Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 1
Intervention: Drug: controlled-release oral alpha-lipoic acid
14 Completed Antioxidant Functions of Lipoic Acid
Condition: Hypercholesterolemia
Intervention: Drug: lipoic acid
15 Recruiting Effect of Alpha Lipoic Acid on Obesity Related Comorbidities
Conditions: Obesity; Cardiovascular Disease; Type 2 Diabetes
Interventions: Dietary Supplement: Alpha Lipoic Acid; Dietary Supplement: Placebo
16 Completed Painful HIV Neuropathy and Alpha-Lipoic Acid
Conditions: HIV; Peripheral Neuropathy
Intervention: Drug: Alpha-Lipoic Acid
17 Completed Immune Restoration by Lipoic Acid in AIDS
Conditions: Acquired Immunodeficiency Syndrome; HIV Infections
Intervention: Drug: Alpha Lipoic Acid
18 Active, not recruiting Alpha Lipoic Acid and Polycystic Ovary Syndrome
Conditions: Insulin Resistance; Oxidative Stress
Intervention: Dietary Supplement: Alpha Lipoic Acid
19 Active, not recruiting Effect of Long Term α-Lipoic Acid Treatment on Endothelial Function in Patients With Type 2 Diabetes
Condition: Type 2 Diabetes
Intervention: Drug: Alpha lipoic acid
20 Active, not recruiting Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer
Conditions: Neurotoxicity; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: alpha-lipoic acid; Other: placebo

[Celebration]

2. Used in late stage pancreatic cancer, successfully

Dr. Berkson has successfully used infusions of alpha lipoic acid along with low dose naltrexone for late stage "incurable" pancreatic cancers.

http://www.ncbi.nlm.nih.gov/pubmed/20042414

[HysteryDiagnosis]

3. Diabetic neuropathy as well... this is one person's experience, actual

clinical trials have backed this up.


My name is Chris Stiehl. I have had diabetes for over 45 years. About 25 years ago, I began losing sensation in my feet due to peripheral neuropathy caused by diabetes. There was extreme “phantom” pain in my feet and toes as the nerves died. The situation progressed until I had no feeling in my feet up to my ankles.

A few years ago, I was visiting my in-laws over the fourth of July. I was standing on concrete near their pool when I noticed my niece hopping around due to the hot pavement when she left the pool. Needless to say, I couldn’t feel the hot concrete below my feet! I suffered large blisters on both feet as a result of “forgetting” for a few minutes that I was diabetic and had no feeling in my feet. Both feet healed over several months, but one had a small staph infection inside where it had healed. Eventually, I had to have my toes amputated on that foot, from the metatarsil joints forward. It was an unpleasant reward for forgetting that I had lost sensation in my feet.

Not too long after, I had a trip to San Francisco from my home in San Diego. Once I was airborne, I threw my keys into my tennis shoes in my suitcase. When I got home a few days later, I couldn’t remember where I put the keys to get into my own house. Then I realized I was wearing the tennis shoes. I had driven home and walked in the shoes without realizing all my keys were in my shoe! I had jammed my foot into the shoe and felt nothing!

I began taking Glucotize (time release alpha-lipoic acid). For the first three months, I didn’t notice any change in sensation. Then I began to be able to sense when I was standing on a cold tile floor, such as in my bathroom. This was a miracle to me, as I hadn’t had any such sensation in years. I could feel the texture of the floor (carpet versus wood or tile).

While at work one day, I popped a bag of popcorn. One of the unpopped kernels fell into my shoe. I found out when I stood and felt the kernel in my shoe! This was amazing to me! It was the same foot where I had not felt the whole wad of keys just months before! It felt like a miracle to me!

I had been told that my nerve damage was irreversible. I do not have complete recovery of nerve function, but I have recovered a lot of what had been lost! I have also noticed improvements in other conditions resulting from nerve damage caused by diabetes (sharp phantom pains, stomach acidity, sexual functioning, etc.).

I believe in Glucotize as it has restored function in nerves that had been a problem for me for years. I am very pleased to endorse this product. I believe in it!

- Chris

[trotsky]

4. ZOMG a totally unverifiable personal anecdote found on.... wait for it...

the website of the company who sells this supplement!

I really don't know how anyone could doubt this miracle cure.

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