Childhood Allergy and prebiotics, not drugs, not chemicals, but

[HysteryDiagnosis]

PREBIOTICS, things that belong in you gut, not things that don't. Sweep away.



Research on diet and nutrition published by scientists at University of Milan

NewsRx.com

06-27-08

"A mixture of neutral short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (IcFOS) has been shown to reduce the incidence of atopic dermatitis (AD) and infectious episodes during the first 6 mo of life. This dual protection occurred through the intervention period," investigators in Milan, Italy report (see also Diet and Nutrition).

"The present study evaluated if these protective effects were lasting beyond the intervention period. In a prospective, randomized, double-blind, placebo-controlled design, healthy term infants with a parental history of atopy were fed either a prebiotic-supplemented (8 g/L scGOS/IcFOS) or placebo-supplemented (8 g/L maltodextrin) hypoallergenic formula during the first 6 mo of life. Following this intervention period, blind follow-up continued until 2 y of life. Primary endpoints were cumulative incidence of allergic manifestations. Secondary endpoints were number of infectious episodes and growth. Of 152 participants, 134 infants (68 in placebo, 66 in intervention group) completed the follow-up. During this period, infants in the scGOS/IcFOS group had significantly lower incidence of allergic manifestations.

Cumulative incidences for AD, recurrent wheezing, and allergic urticaria were higher in the placebo group, (27.9, 20.6, and 10.3%, respectively) than in the intervention group (13.6, 7.6, and 1.5%) (P < 0.05). Infants in the scGOS/IcFOS group had fewer episodes of physician-diagnosed overall and upper respiratory tract infections (P < 0.01), fever episodes (P < 0.00001), and fewer antibiotic prescriptions (P < 0.05). Growth was normal and similar in both groups. Early dietary intervention with oligosaccharide prebiotics has a protective effect against both allergic manifestations and infections," wrote S. Arslanoglu and colleagues, University of Milan.

The researchers concluded: "The observed dual protection lasting beyond the intervention period suggests that an immune modulating effect through the intestinal flora modification may be the principal mechanism of action."

Arslanoglu and colleagues published their study in the Journal of Nutrition (Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. Journal of Nutrition, 2008;138(6):1091-1095).

For additional information, contact S. Arslanoglu, University of Milan, Macedonio Melloni Hospital, Center Infant Nutrition, I-20129 Milan, Italy.

The publisher of the Journal of Nutrition can be contacted at: American Society Nutritional Science, 9650 Rockville Pike, RM L-2407A, Bethesda, MD 20814, USA.

Keywords: Italy, Milan, Life Sciences, Pediatrics, Dermatology, Atopic Dermatitis, Alternative Medicine, Therapy, Treatment, Diet and Nutrition, University of Milan.

This article was prepared by Physician Law Weekly editors from staff and other reports. Copyright 2008, Physician Law Weekly via NewsRx.com.

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

[enki23]

1. er... even if everything said in that were true...

those *are* chemicals. and, as used, drugs.

[HysteryDiagnosis]

2. The human body contains roughly 60 trillion cells. It also hopefully

contains 100 trillion bacteria both friendly and non-friendly in the digestive tract. If you want to call something that already lives in many people and should live in all people a drug then play through. I prefer to realize the fact that many allergic conditions, digestive disorders, auto-immune conditions yada yada yada are tied to having intestinal dysbiosis. You can call this whatever you like, a disease perhaps.... but an easily corrected one in many instances without the use of steroids, chemicals, or drugs of any sort.

[cosmik debris]

3. Those are impressive numbers. Did you make them up? n/t

[HysteryDiagnosis]

4. I make up a lot of things.... those numbers weren't two of

them.

Re: Number of cells in an adult human
Date: Fri Mar 6 14:50:27 1998
Posted By: Thomas M. Greiner, Assistant Professor of Anatomy / Physical Anthropology, New York Chiropractic College
Area of science: Anatomy
ID: 888524762.An Message:

How many cells are in an adult human? Lots. More than anyone could count, and the bigger you are the more cells there would be. Growth is a process of cellular reproduction, so as you grow bigger you are made up of more cells. Following a similar logic, a larger person is larger because they have more cells, not because their cells are larger. In fact, cell types have a fairly uniform size across the entire human species.

The largest and smallest cells in the human body are the gametes, or the sex cells. The female sex cell, the oocyte, is about 35 microns in diameter, which puts it just on the edge of being visible if you have real good eyes. The male sex cell, spermatozoan, cell is only about 3 microns in diameter, and therefore is the smallest cell of the human body. Various other cell types have various other sizes within this range.

Admin note: Although no exact number can be given, the order of magnitude of the number of cells in a human body can be approximated to 10 14 or one hundred trillion cells.

http://www.madsci.org/posts/archives/1998-03/889221957.An.r.html

Bacteria Outnumber Cells in Human Body

Listen Now <4 min 0 sec> add to playlist

All Things Considered, July 1, 2006 · The human body contains 20 times more microbes than it does cells. In fact, a visitor from outer space might think the human race is just one big chain of microbe hotels.

[cosmik debris]

5. So, you didn't make it up, you just mis-reported.

I had to ask because your credibility is so bad after all the other "mistakes" you have made.

So why do you say sixty trillion in one post and one hundred trillion in another post?

You really should work on your accuracy.

And if, as you say, "The human body contains 20 times more microbes than it does cells." 20 times 100 is not 100. Even 20 time 60 is not 100. There is no way these numbers agree with your post. Your math could certainly use some improvement.

[HysteryDiagnosis]

6. Dude, you dwell on insignificant little details..... why don't you

just try to counter the findings of the truly grand and revelatory research. That would be a great start for a much heated debate. I missed you btw.

[cosmik debris]

7. I'm just trying to make the point

That nothing you say can be trusted.

And you certainly proved that!

And if those are "insignificant little details" why did you bring them up?

[HysteryDiagnosis]

9. So what do you think about the fact that the makeup and content

of one's intestinal flora SERIOUSLY affects one's well being?? Try to be truthful dear.

[cosmik debris]

13. I understand the value of intestinal flora.

I don't understand why you are rambling incoherently about how chemicals are not chemicals, drugs are not drugs, things that don't live but do live, and arithmetic that doesn't add up.

But thanks for asking, sweetheart.

[HysteryDiagnosis]

18. Some substances are natural foods and or nutrients that

belong in the human body. Others not so much.

[cosmik debris]

21. And those substances are called

chemicals.

[HysteryDiagnosis]

22. If you prefer. I'll call my food chemicals from now on. I hope the

court is pleased. Now Prozac?? I'll call that breakfast cereal.

[TZ]

25. Intestinal flora are important

But like everything else you state in here, you have overblown their importance. I would wonder how many other factors were involved in this study, including whether or not the families have histories of allergies, what other foods the children are eating or not eating..ect...There is a very good reason I spend my days working on experiments with ANTIBODIES..Those are the BIG FACTOR in immunology..intestinal flora is secondary in this respect.

[HysteryDiagnosis]

26. Then you will appreciate this.

1: J Nutr. 2008 Jun;138(6):1141-7.Click here to read Links
Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides.
Scholtens PA, Alliet P, Raes M, Alles MS, Kroes H, Boehm G, Knippels LM, Knol J, Vandenplas Y.

Numico Research, Wageningen 6700 CA, The Netherlands. [e-mail]

In this double-blind, randomized, placebo-controlled study, we investigated the effect of an infant milk formula with 6 g/L short-chain galacto- and long-chain fructo-oligosaccharides <(scGOS/lcFOS) ratio 9:1> on the development of the fecal secretory immunoglobulin A (sIgA) response and on the composition of the intestinal microbiota in 215 healthy infants during the first 26 wk of life. The infants received breast milk or were randomized to receive an infant milk formula with or without scGOS/lcFOS. Stool samples were collected after 8 and 26 wk of intervention. The concentration of fecal sIgA was determined by ELISA, and the composition of the intestinal microbiota was determined by quantitative fluorescent in situ hybridization.

The scGOS/lcFOS group and the control group were compared in the statistical analysis. A breast fed group was included as a reference. In total, 187 infants completed the study. After 26 wk of intervention, in infants that were exclusively formula fed, the concentration of sIgA was higher (P < 0.001) in the scGOS/lcFOS group (719 microg/g) than in the control group (263 microg/g). In addition, the percentages of bifidobacteria were higher in the scGOS/lcFOS group (60.4%) than in the control group (52.6%, P = 0.04). The percentages of Clostridium spp. were 0.0 and 3.27%, respectively (P = 0.006). In conclusion, an infant milk formula with 6 g/L scGOS/lcFOS results in higher concentrations of fecal sIgA, suggesting a positive effect on mucosal immunity.

[cosmik debris]

8. Are you aware that

galactooligosaccharides and fructooligosaccharides are not biological creatures but long chain sugars?

They are not alive.

They are chemicals.

They do not live in the body.

They do not live at all.

[HysteryDiagnosis]

10. Well duh.... hence the term "prebiotics". Any fool would know that.

Don't you love the little ads from the nasty supplement manufacturers at the top of the page??

[cosmik debris]

11. Well, YOU made the statement

"If you want to call something that already lives in many people and should live in all people a drug then play through." when referring to these chemicals.

And in the OP you (falsely) denied that they are chemicals.

I could only guess that you believed that these chemicals "already lives in many people and should live in all people".

You certainly aren't making any sense.

And it certainly looks like you thought that these chemicals lived when it is clear that they don't.

So now we can add incomprehensible to your reputation for being unreliable.

[HysteryDiagnosis]

12. I get the impression that you don't care for my message

very much.... pity that.

[cosmik debris]

14. I don't know what your message is???????

You are rambling incoherently.

[HysteryDiagnosis]

15. I'm a ramblin ramblin ramblin cowpoke.. yeah, that's what I am

Address the original premise that altering the intestinal environment can lead to a trememdous reduction in allergic responses by the human frame. All you have to do at this point is say "yes" this is a truism. Then we can move on to better things. Don't you want to move on to better things?

[cosmik debris]

16. Not really

I rather enjoy watching you ramble incoherently and prove that you are incomprehensible and unreliable. Your math example will go down in history as one of your best posts ever! :)

[HysteryDiagnosis]

17. Oh behave!! My math example.... how gosh. Try again. n/t

[cosmik debris]

19. Let's recap your math example.

In post #2 you say:

Number of cells in a human body = 60 trillion
Number of bacteria in a human body = 100 trillion

When challenged on those numbers you presented "supporting" evidence that:

Number of cells in a human body = 100 trillion
Number of bacteria in a human body = 20 times 100 trillion

So, clearly you were wrong in one or more cases.

The funny part is that YOU PROVED YOURSELF WRONG! And that's funny, but we all know that it wasn't the first time you have proved yourself wrong.

And if your "how gosh" was meant to say "How gauche!", you should learn to spell in French before you try to use French words.

[Name removed]

20. Deleted sub-thread

Sub-thread removed by moderator. Click here to review the message board rules.

[grasswire]

29. what the hell is wrong with you?

And why are you allowed to continue this garbage?

[cosmik debris]

30. Life is a carnival--believe it or not

Life is a carnival--two bits a shot

[Orrex]

23. Well, shit

And here's me, all ready to go and get my colon cleansed by Dr. Stool's Craptacular Detoxifying enema tonics.

Thanks for the warning.

[TZ]

24. Umm digestive flora has nothing to do with formation of wbc's

including various forms of Immunoglobulins--which is what CAUSES allergies, along with histimines and such. Prebiotics make your digestion better but to say they are gonna keep you from having allergies...thats pretty outthere. And if you knew anything about the stuff you babble you would know that.
Sorry, eating yogurt isn't gonna prevent asthma and allergies..It has to do with immunology..in fact there is growing evidence that the over protective people who keep their very young children from being exposed to pathogens (including getting vaccinated) so they can develop the PROPER antibodies are more likely to have kids that develop allergies..well that and GENETICS...which again, eating yogurt (which is what probiotics are) does zip.

[BuddhaGirl]

27. I know two different friends who have given their children

probiotics - not in the form of yogurt, but it capsule form. In both cases, it improved the allergies in their kids...the kids were not taking anything else for allergies, either. Based on this, my DH started taking probiotics for his allergies, and he got the same results. So your statement that "probiotics does zip" is inaccurate, according to my perspective, and those of my friends.

Yeah, I know it's "anecdotal" - so you won't care much. But that's okay with me

:hi:

[Celebration]

28. Here is the Medline Abstract of the study

1: J Nutr. 2008 Jun;138(6):1091-5. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life.Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G.
Center for Infant Nutrition, Macedonio Melloni Hospital, University of Milan, Milan 20129, Italy. [e-mail]

A mixture of neutral short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) has been shown to reduce the incidence of atopic dermatitis (AD) and infectious episodes during the first 6 mo of life. This dual protection occurred through the intervention period. The present study evaluated if these protective effects were lasting beyond the intervention period. In a prospective, randomized, double-blind, placebo-controlled design, healthy term infants with a parental history of atopy were fed either a prebiotic-supplemented (8 g/L scGOS/lcFOS) or placebo-supplemented (8 g/L maltodextrin) hypoallergenic formula during the first 6 mo of life. Following this intervention period, blind follow-up continued until 2 y of life. Primary endpoints were cumulative incidence of allergic manifestations. Secondary endpoints were number of infectious episodes and growth. Of 152 participants, 134 infants (68 in placebo, 66 in intervention group) completed the follow-up. During this period, infants in the scGOS/lcFOS group had significantly lower incidence of allergic manifestations. Cumulative incidences for AD, recurrent wheezing, and allergic urticaria were higher in the placebo group, (27.9, 20.6, and 10.3%, respectively) than in the intervention group (13.6, 7.6, and 1.5%) (P < 0.05). Infants in the scGOS/lcFOS group had fewer episodes of physician-diagnosed overall and upper respiratory tract infections (P < 0.01), fever episodes (P < 0.00001), and fewer antibiotic prescriptions (P < 0.05). Growth was normal and similar in both groups. Early dietary intervention with oligosaccharide prebiotics has a protective effect against both allergic manifestations and infections. The observed dual protection lasting beyond the intervention period suggests that an immune modulating effect through the intestinal flora modification may be the principal mechanism of action.

PMID: 18492839

[chicagomd]

31. Bad math aside,

That is almost as cool as the helmith article.

Better living through chemicals, and worms!