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The Influenza Pandemic of 1918 - Great, well-sourced research paper by Molly Billings, June, 1997

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pinto Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 02:32 PM
Original message
The Influenza Pandemic of 1918 - Great, well-sourced research paper by Molly Billings, June, 1997
Great read, especially if you're interested in the history of disease and/or Public Health. Origins, spread and effects, medical and social, of the "Spanish Flu". Includes sections, 'The Public Health Response' and 'The Scientific and Medical Response'. Has a lot of first-hand reports and a complete bibliography of cited sources. ~ pinto

http://virus.stanford.edu/uda/index.html

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The Influenza Pandemic of 1918

The influenza pandemic of 1918-1919 killed more people than the Great War, known today as World War I (WWI), at somewhere between 20 and 40 million people. It has been cited as the most devastating epidemic in recorded world history. More people died of influenza in a single year than in four-years of the Black Death Bubonic Plague from 1347 to 1351. Known as "Spanish Flu" or "La Grippe" the influenza of 1918-1919 was a global disaster.

In the fall of 1918 the Great War in Europe was winding down and peace was on the horizon. The Americans had joined in the fight, bringing the Allies closer to victory against the Germans. Deep within the trenches these men lived through some of the most brutal conditions of life, which it seemed could not be any worse. Then, in pockets across the globe, something erupted that seemed as benign as the common cold. The influenza of that season, however, was far more than a cold. In the two years that this scourge ravaged the earth, a fifth of the world's population was infected. The flu was most deadly for people ages 20 to 40. This pattern of morbidity was unusual for influenza which is usually a killer of the elderly and young children. It infected 28% of all Americans (Tice). An estimated 675,000 Americans died of influenza during the pandemic, ten times as many as in the world war. Of the U.S. soldiers who died in Europe, half of them fell to the influenza virus and not to the enemy (Deseret News). An estimated 43,000 servicemen mobilized for WWI died of influenza (Crosby). 1918 would go down as unforgettable year of suffering and death and yet of peace. As noted in the Journal of the American Medical Association final edition of 1918:

"The 1918 has gone: a year momentous as the termination of the most cruel war in the annals of the human race; a year which marked, the end at least for a time, of man's destruction of man; unfortunately a year in which developed a most fatal infectious disease causing the death of hundreds of thousands of human beings. Medical science for four and one-half years devoted itself to putting men on the firing line and keeping them there. Now it must turn with its whole might to combating the greatest enemy of all--infectious disease," (12/28/1918).

The effect of the influenza epidemic was so severe that the average life span in the US was depressed by 10 years. The influenza virus had a profound virulence, with a mortality rate at 2.5% compared to the previous influenza epidemics, which were less than 0.1%. The death rate for 15 to 34-year-olds of influenza and pneumonia were 20 times higher in 1918 than in previous years (Taubenberger). People were struck with illness on the street and died rapid deaths. One anectode shared of 1918 was of four women playing bridge together late into the night. Overnight, three of the women died from influenza (Hoagg). Others told stories of people on their way to work suddenly developing the flu and dying within hours (Henig). One physician writes that patients with seemingly ordinary influenza would rapidly "develop the most viscous type of pneumonia that has ever been seen" and later when cyanosis appeared in the patients, "it is simply a struggle for air until they suffocate," (Grist, 1979). Another physician recalls that the influenza patients "died struggling to clear their airways of a blood-tinged froth that sometimes gushed from their nose and mouth," (Starr, 1976). The physicians of the time were helpless against this powerful agent of influenza. In 1918 children would skip rope to the rhyme (Crawford):

I had a little bird,
Its name was Enza.
I opened the window,
And in-flu-enza.


The influenza pandemic circled the globe. Most of humanity felt the effects of this strain of the influenza virus. It spread following the path of its human carriers, along trade routes and shipping lines. Outbreaks swept through North America, Europe, Asia, Africa, Brazil and the South Pacific (Taubenberger). In India the mortality rate was extremely high at around 50 deaths from influenza per 1,000 people (Brown). The Great War, with its mass movements of men in armies and aboard ships, probably aided in its rapid diffusion and attack. The origins of the deadly flu disease were unknown but widely speculated upon. Some of the allies thought of the epidemic as a biological warfare tool of the Germans. Many thought it was a result of the trench warfare, the use of mustard gases and the generated "smoke and fumes" of the war. A national campaign began using the ready rhetoric of war to fight the new enemy of microscopic proportions. A study attempted to reason why the disease had been so devastating in certain localized regions, looking at the climate, the weather and the racial composition of cities. They found humidity to be linked with more severe epidemics as it "fosters the dissemination of the bacteria," (Committee on Atmosphere and Man, 1923). Meanwhile the new sciences of the infectious agents and immunology were racing to come up with a vaccine or therapy to stop the epidemics.

<snip>

http://virus.stanford.edu/uda/index.html

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see also - Fact sheet from the Visiting Nurse Associations of America (VNAA) 'Pandemic Influenza and H1N1 History Fact Sheet' - http://www.vnaa.org/vnaa/g/?h=html/doc/H1N1_History.pdf - for an overview of the 'Spanish Flu' and H1N1. The section on the flu of 1918 is mainly a cut and paste from Ms. Billings' paper, but the fact sheet also has a good thumbnail history of H1N1.
~ pinto



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Warpy Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 02:39 PM
Response to Original message
1. Mortality from H1N1 in the developed world
this time is likely to be lower than 2.5% because fewer people will die from treatable bacterial pneumonia superinfections.

This is likely to equal the 1918 flu in underdeveloped countries, especially in the bush where few medical services are available.

Please, if you're under 60, get the shot. If you're over 60, get it after the high risk groups have gotten theirs.
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pinto Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 02:42 PM
Response to Reply #1
2. Yeah, good points.
:thumbsup:
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stray cat Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 02:51 PM
Response to Reply #1
4. Actually nearly 10% of those in intensive care still die in the US
Edited on Sun Oct-18-09 02:54 PM by stray cat
Only 30% of the dead have complications due to bacterial infection http://www.msnbc.msn.com/id/33243690/ns/health-swine_flu/?ns=health-swine_flu
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Warpy Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 03:00 PM
Response to Reply #4
5. That is exactly what I'd expect to see in the US
Edited on Sun Oct-18-09 03:01 PM by Warpy
because the secondary infections are being treated at home with antibiotics.

They were certain death in 1918 unless the people who had them were exceptionally strong.

That's why the overall death rate is lower than it was in 1918. It will likely be as high or higher in the underdeveloped world, especially in the bush.
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panader0 Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 02:47 PM
Response to Original message
3. I'm currently reading 'The Given Day' a great novel by Dennis Lehane
It takes place in Boston during time of the flu. Very good so far.
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CHIMO Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 07:09 PM
Response to Original message
6. Thank You
For posting this article. Quite timely.

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bertman Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 09:56 PM
Response to Original message
7. Interesting read. I never knew the effects worked so quickly to kill people. Rec.
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friendly_iconoclast Donating Member (1000+ posts) Send PM | Profile | Ignore Sun Oct-18-09 11:21 PM
Response to Original message
8. A good history of the 1918 flu is "The Great Influenza" by John M. Barry
subtitled: The Epic Story of the Deadliest Plague In History

A fascinating (if sobering) read. Barry argues (with good evidence) that the 1918 mutated into its deadliest
strain in Kansas.

Much discussion of the failures of public health officials in some cities.
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unhappycamper Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Oct-19-09 04:11 AM
Response to Reply #8
11. This is one of the best books I've read about that pandemic.
IIRC, the pandemic started on a farm outside of Ft. Riley, KS. Movement of troops around the country and 'over there' spread the virus wide and far. Another book, "Paris 1919", speculated that the reason the middle east was drawn the way it was is because President Wilson caught the flu and was ill for most of the conference in Versailles.
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undergroundpanther Donating Member (1000+ posts) Send PM | Profile | Ignore Mon Oct-19-09 12:01 AM
Response to Original message
9. Then why did they dig it up again?
Scientists Describe How 1918 Influenza Virus Sample Was Exhumed In Alaska

ScienceDaily (July 4, 2007) — The effort to find preserved samples of the 1918 influenza virus has been a pursuit of both historical and medical importance. The 1918 influenza pandemic was the most devastating single disease outbreak in modern history, and examining the virus that caused it may help prepare for, and possibly prevent, future pandemics. When the complete sequence of the 1918 virus was published in 2005, it represented a watershed event for influenza researchers worldwide.

http://www.sciencedaily.com/releases/2007/07/070702145610.htm


Recently, scientists were able to remake 1918 flu using a technique called reverse genetics. They started by making DNA copies of the virus genome segments because DNA is easier to manipulate in the lab than RNA. Each of those copies was then placed into a larger piece of circular DNA called a plasmid. Those eight DNA circles are then put into an animal cell. The animal cell produces the proteins that correspond to the 8 segments which then form the flu virus. The technique also allows scientists to selectively manipulate individual parts of the virus when doing experiments.

Mechanism: Flu strains are named for the H and N proteins, hemagglutinin and neuraminidase, which stick out from the surface of the virus like spikes. These protein spikes allow influenza to infect and damage cells and are what the immune system recognizes. The hemagglutinin spike allows the virus to bind to and enter cells. After co-opting the cells molecular machinery to produce more viruses, the neuraminidase spike is used to escape the cell, destroying it in the process. The 1918 influenza is an H1N1 strain and research on the reconstituted virus shows that it was particularly infective and had the unusual property of being able to infect mice, which typical human influenza strains cannot.

http://www.fas.org/programs/ssp/bio/factsheets/H1N1factsheet.html


Emergence of a Virus

Simultaneous Appearance in Humans and Swine (1918)

Before 1918, influenza in humans was well known, but the disease had never been described in pigs.3 For pig farmers in Iowa, everything changed after the Cedar Rapids Swine Show, which was held from September 30 to October 5 of that year.4 Just as the 1918 pandemic spread the human influenza A (H1N1) virus worldwide and killed 40 million to 50 million people, herds of swine were hit with a respiratory illness that closely resembled the clinical syndrome affecting humans. Similarities in the clinical presentations and pathologic features of influenza in humans and swine suggested that pandemic human influenza in 1918 was actually adapted to the pig, and the search for the causative agent began.
http://content.nejm.org/cgi/content/full/NEJMra0904322

Why were the viral genomes of the 1977 H1N1 isolate and the 1950 virus so similar? If the H1N1 viruses had been replicating in an animal host for 27 years, far more genetic differences would have been identified. The authors suggested several possibilities, but only one is compelling:

…it is possible that the 1950 H1N1 influenza virus was truly frozen in nature or elsewhere and that such a strain was only recently introduced into man.

The suggestion is clear: the virus was frozen in a laboratory freezer since 1950, and was released, either by intent or accident, in 1977. This possibility has been denied by Chinese and Russian scientists, but remains to this day the only scientifically plausible explanation.

http://www.virology.ws/2009/03/02/origin-of-current-influenza-h1n1-virus/

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The Second Stone Donating Member (603 posts) Send PM | Profile | Ignore Mon Oct-19-09 02:26 AM
Response to Original message
10. My cousin Patty died of H1N1 on Oct 12
I just got back from her memorial. 52 years old, two teenage girls and a loving husband and mother left behind. She was in a hospital getting good care. The two daughters look just like their Mom did four decades ago. We were not close, but I feel so badly for those little girls.
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