Tamiflu-Resistance Gene in H7N9 Bird Flu Spurs Drug Tests

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http://www.bloomberg.com/news/2013-04-11/tamiflu-resistance-gene-in-h7n9-bird-flu-spurs-drug-tests.html

A gene mutation known to help influenza resist Tamiflu was found in the first of three H7N9 bird-flu patient specimens in China, sequence data show.

The flu virus from the patient in Shanghai has a mutation known as R292K that causes high-level resistance to the Roche Holding AG (ROG) pill and reduced sensitivity to a related drug from GlaxoSmithKline Plc (GSK) called Relenza, genetic sequence information posted on the website of the Global Initiative on Sharing Avian Influenza Data show. Subsequent H7N9 specimens from a patient in Shanghai and one in Anhui province don’t show the mutation.

The finding of the mutation warrants further analysis, said Masato Tashiro, a director at Japan’s National Institute of Infectious Diseases in Tokyo. Preliminary tests so far show no evidence that the new flu strain, which has sickened at least 33 people, killing nine, in eastern China, has developed resistance to the neuraminidase inhibitor drugs Tamiflu and Relenza, the World Health Organization said in a statement yesterday.

“When you look at the raw data and compare the three strains of the virus, there’s a signal from one strain that it’s less sensitive to both of the neuraminidase inhibitors,” Tashiro said in a telephone interview. “It’s not a strong signal, but there’s a possibility” of resistance, he said.